Release of Chromium from Orthopaedic Hip & Knee Replacements

My view:

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• Many orthopaedic implants are composed of alloys containing chromium.
• There is an increasing number of Cobalt Chromium hip and knew replacements being inserted into young patients with osteoarthritis.
• Such implants will release chromium ions.
• These patients will be exposed to the released chromium for over 50 years in some cases.
• The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex and most likely to be damaging.
• In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL).

Source:

The Open Orthopaedics Journal, 2008, 2, 10-18; 1874-3250/08 2008 Bentham Science Publishers Ltd.

G.A. Afolaranmi1, J. Tettey1, R.M.D. Meek*,2 and M.H. Grant3; 1Strathclyde Institute of Pharmacy and Biomedical Sciences, 2Department of Orthopaedic Surgery, Southern General Hospital, Glasgow, UK, 3Bioengineering Unit, University of Strathclyde, UK

Technorati Tags: Chrome Poisoning , Cobalt Ions, Cobalt Poisoning, hip prosthesis, Hip Replacement, Metal Hypersensitity, Metal Ions, risk factors, Hexavalent Chrome, Chrome VI, Hip recall, Hip Revision, orthopaedic implants, DNA Damage, Chromosomal Damage

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